Protein Misfolding vs. Alzheimer Disease
Folding Conformations of Amyloid Beta-42

• The major components of neurotic plaques found in Alzheimer Disease (AD) are peptides known as amyloid beta-peptides (A-beta-42).
• In vitro amyloid beta-peptides may undergo a conformational transition from a soluble form to aggregated fibrillary b-sheet structures, which seem to be neurotoxic.
• Conformational studies on these peptides in aqueous solution are complicated by their tendency to aggregate.
• Compare the NMR conformers of A-beta-(1-42) of 1Z0Q and 1IYT in aqueous media to reveal the misfolding, alpha-to-beta conformational transition

 

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More Applications

Objective	Application
Complete Protein Folding Information	Reveal the nature of protein folding variations
Mutation and Conformation Change	Mutation vs. change in folding conformation
Antibody CDR Loops Fingerprint	Antibody (Rituximab) of CD20 fingerprint
Antibody Design and Optimization	Antibody optimization by fingerprint
Peptide Design	Design peptide for a specific folding conformation
Protein Conformation Alignment	Comparison of protein conformations
Conformation Analysis	Expose similarity and dissimilarity for conformers
Protein Conformation Comparison	Comparison between Insulin Receptor and IGF-1 Receptor
Protein Misfolding	Misfolding in Amyloid Beta-42
Conformation Search	Similarity score for conformation search
Drug Binding Site	ATP Binding Sites on Kinases
Probe Binding Site for Drug Discovery	Predict multiple protein targets for drug