Antibody CDR Loops Fingerprint
Monoclonal Antibody (Rituximab) of CD20

     

     

  • The general structure of all antibodies is very similar
  • It is composed of one constant and one variable domain from each heavy and light chain of the antibody
  • The loops at the tip are referred to as the complementarily determining regions (CDRs)
  • The CDR loops are extremely variable, allowing millions of antibodies with slightly different tip structures, as antigen binding sites

     

     

  • Rituximab is a widely used monoclonal antibody drug for treating certain lymphomasand autoimmune diseases. It is a chimeric monoclonal antibody against the protein CD20, which is primarily found on the surface of B cells.
  • There are two protein structure data (3BKY and 2OSL) available in PDB
  • Fingerprint comparison for CDR loops of monoclonal antibody (Rituximab) is show below table.

 

 

 

Antigen-Antibody Recognition & Binding: Rituximab Fab fragment in complex with an epitope peptide of the large extra-cellular loop (residues 163–187) of CD20.

 

 

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More Applications

Objective Application
Reveal the nature of protein folding variations
Mutation vs. change in folding conformation
Antibody (Rituximab) of CD20 fingerprint
Antibody optimization by fingerprint
Design peptide for a specific folding conformation
Comparison of protein conformations
Expose similarity and dissimilarity for conformers
Comparison between Insulin Receptor and IGF-1 Receptor
Misfolding in Amyloid Beta-42
Similarity score for conformation search
ATP Binding Sites on Kinases
Predict multiple protein targets for drug

 

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