Antibody CDR Loops Fingerprint
Monoclonal Antibody (Rituximab) of CD20



  • The general structure of all antibodies is very similar
  • It is composed of one constant and one variable domain from each heavy and light chain of the antibody
  • The loops at the tip are referred to as the complementarily determining regions (CDRs)
  • The CDR loops are extremely variable, allowing millions of antibodies with slightly different tip structures, as antigen binding sites



  • Rituximab is a widely used monoclonal antibody drug for treating certain lymphomasand autoimmune diseases. It is a chimeric monoclonal antibody against the protein CD20, which is primarily found on the surface of B cells.
  • There are two protein structure data (3BKY and 2OSL) available in PDB
  • Fingerprint comparison for CDR loops of monoclonal antibody (Rituximab) is show below table.




Antigen-Antibody Recognition & Binding: Rituximab Fab fragment in complex with an epitope peptide of the large extra-cellular loop (residues 163–187) of CD20.




More Applications

Objective Application
Reveal the nature of protein folding variations
Mutation vs. change in folding conformation
Antibody (Rituximab) of CD20 fingerprint
Antibody optimization by fingerprint
Design peptide for a specific folding conformation
Comparison of protein conformations
Expose similarity and dissimilarity for conformers
Comparison between Insulin Receptor and IGF-1 Receptor
Misfolding in Amyloid Beta-42
Similarity score for conformation search
ATP Binding Sites on Kinases
Predict multiple protein targets for drug


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